Paracrine functions of fibrocytes to promote lung fibrosis

Fibrocytes in Scleroderma Lung Fibrosis

Systemic sclerosis (SSc) or “Scleroderma” is a disease characterized by cutaneous and visceral fibrosis that affects both the skin and internal organs. The worldwide prevalence ranges from 50-300 cases per million (Chifflot et al., 2008) and much of the morbidity in this population results from pulmonary complications. In fact, nearly 70% of scleroderma patients show some form of lung disease. ...

Role of Circulating Fibrocytes in Cardiac Fibrosis

OBJECTIVE It is revealed that circulating fibrocytes are elevated in patients/animals with cardiac fibrosis, and this review aims to provide an introduction to circulating fibrocytes and their role in cardiac fibrosis. DATA SOURCES This review is based on the data from 1994 to present obtained from PubMed. The search terms were "circulating fibrocytes " and "cardiac fibrosis ". STUDY SELECT...

Fibrocytes in pulmonary fibrosis: a brief synopsis.

Fibrocytes are bone marrow-derived, circulating mesenchymal progenitor cells that play a role in several fibrotic disorders, including lung fibrosis. They are attracted to injured tissue by various chemokines. It is likely that fibrocytes play a detrimental role in tissue homeostasis and promote fibrosis, although this paradigm needs further confirmation. This would make fibrocytes a possible n...

Fibrocytes: a new insight into kidney fibrosis.

Fibrocytes are supposed to be a circulating connective tissue cell progenitor, which consists of a novel population of peripheral blood cells. This distinct population of blood-borne cells shares markers of leukocytes as well as mesenchymal cells. Accumulating evidence indicates that fibrosis is characteristic of progressive chronic kidney diseases of any etiologies, resulting in kidney failure...

Type I Collagen during Lung Fibrosis Fibrocytes Are Not an Essential Source of